“It is the job of a satirist to make people in power uncomfortable. Really uncomfortable.”

That was Tony Hendra, and he knew whereof he spoke. Hendra, who died of Lou Gehrig’s disease on Thursday, helped make a lot of people very uncomfortable indeed with his work for National Lampoon and Spy magazine, among others.

Had it not been for the trailblazing Lampoon some of us would have laughed a great deal less over the past half century. The magazine had a nut-crushing stable of funnymen, among them Hendra himself. And its “Radio Dinner,” “The National Lampoon Radio Hour,” and “Lemmings” led directly to “Saturday Night Live,” “Animal House,” “This Is Spinal Tap,” and the “Vacation” movie franchise.

Hendra’s “Magical Misery Tour” was a brutal takedown of John Lennon using Lennon’s own words from an interview in Rolling Stone. I bet John wasn’t laughing when he heard that one.

Hendra may not be as familiar to you as Chevy Chase, John Belushi, P.J. O’Rourke, or Christopher Guest. But he was right in there among them, one of the ha-ha mechanics throwing shit, just to see what might stick, and to what, or whom. Making people in power uncomfortable. Really uncomfortable.

One of his last smiles before the disease took those from him came when he learned the results of the last presidential election, said his wife, Carla.

“He was an immigrant who sailed from London into N.Y. Harbor on the SS United States after being given free passage in exchange for performing stand-up,” she told The New York Times. “What was to be a two-week visit became 57 years, because he believed in the promise of America.”